Hayward, Reid

Committee Member

Hydock, David S. (David Scott)

Committee Member

Brustad, Robert John, 1952-


Exercise Physiology


University of Northern Colorado

Type of Resources


Place of Publication

Greeley (Colo.)


University of Northern Colorado

Date Created





145 pages

Digital Origin

Born digital


Many exercise testing protocols used in clinical settings have been developed for apparently healthy (AH) populations, but may be inappropriate for cancer survivors (CS) due to cancer and treatment-related toxicities. The Rocky Mountain Cancer Rehabilitation Institute (RMCRI) developed a cancer specific treadmill protocol to specifically address this issue. Purpose: To assess the validity of the RMCRI multistage treadmill protocol. Methods: 61 participants (45 CS, 16 AH controls) completed three different treadmill protocols, the Bruce (BTP) (for AH subjects), RMCRI without gas analysis (RWOGAP), and RMCRI with gas analysis (RGAP), to compare values of peak oxygen consumption (VO2peak). Participants completed the trials one week apart in random order. Obtained VO2peak values from RGAP were compared against estimated VO2peak from the same gas analysis (GA) test using the American College of Sports Medicine (ACSM) prediction equations (EVACSM). VO2peak from RGAP was also compared to the estimated values of VO2peak achieved during the Bruce protocol. Finally, VO2peak from RGAP was compared against predicted VO2peak values obtained from RWOGAP. Correlations were run between all protocols for each group. Results: For AH participants, no significant differences were observed between any of the VO2peak protocol values (p > 0.05), and positive strong correlations occurred between all protocols (r > 0.8). Among CS,VO2peak between RGAP and BTP were significantly different (p < 0.05). No significant differences in VO2peak values occurred between RGAP and EVACSM (p > 0.05). A positive strong correlation occurred between RGAP VO2peak and EVACSM (r = 0.90), and between VO2peak from the RGAP and RWOGAP (r = 0.81). A moderate positive correlation was observed between VO2peak values from BTP and RGAP (r = 0.51). CS group treadmill time was significantly greater on RWOGAP (12.6 ± 2.8 min) than RGAP (12.1 ± 2.8 min) (p < 0.05). Conclusion: Our findings suggest that the Bruce protocol is not an appropriate protocol for CS. GA equipment may also negatively affect treadmill performance as well. The observed high correlations and validity between predicted and observed VO2peak values suggest that the RMCRI cancer-specific protocol is a valid method of determining VO2peak and should be considered as the standard VO2peak treadmill test for cancer survivors.

Degree type


Degree Name



Rocky Mountain Cancer Rehabilitation Institute


University of Northern Colorado



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