First Advisor
Reid Hayward
First Committee Member
David Hydock
Second Committee Member
Nicholas Pullen
Third Committee Member
James Haughian
Degree Name
Doctor of Philosophy
Document Type
Dissertation
Date Created
8-2023
Department
College of Natural and Health Sciences, Kinesiology Nutrition and Dietetics, KiND Student Work
Abstract
Breast cancer (BC) is one of the leading causes of cancer deaths among females. It is well known that the presence of a tumor decreases robust anticancer immunity via immune-modulation and enhanced immunosuppression through a process called cancer immunoediting. However, it has yet to be determined if exercise-based rehabilitation can elevate the peripheral anticancer immune profile and reduce myeloid-derived suppressor cell (MDSC) mediated immunosuppression. Purpose: To assess the effects of a 12-week prescribed, individualized, supervised exercise-based rehabilitation program on selected circulating immune cells in BC patients at the University of Northern Colorado Cancer Rehabilitation Institute. Methods: 16 female BC patients currently undergoing treatment were divided into a control group (CON, n=7), engaging in normal activities of daily living, and an exercise group (EX, n=9) that participated in 12-weeks of personalized combined aerobic and resistance training three times a week. Venous blood was collected before and after the intervention period and circulating immune cells will be analyzed for frequency and function using flow cytometry. Results: Early (E-) MDSC levels were significantly lower after the exercise intervention compared to the CON group (CON: 18.2±14.5% vs. EX: 5.3±3.6%, p
Abstract Format
html
Language
English
Extent
154 pages
Local Identifiers
HaverbeckSimon_unco_0161D_11153.pdf
Rights Statement
Copyright is held by the author.
Digital Origin
Born digital
Recommended Citation
Haverbeck Simon, Lea, "Effect of Exercise Training on Circulating Cancer-Associated Immune Cells in Breast Cancer Patients" (2023). Dissertations. 1013.
https://digscholarship.unco.edu/dissertations/1013
